Menopause and osteoporosis
• Almost all studies including strong evidenced randomized clinical trials shows that even low doses of estrogen significantly prevent bone loss.
• Combination treatment with estrogen and other common medications used for osteoporosis ( bisphosphonate) was far more superior in preventing bone loss and improving bone density.
• Statement from women health initiative(WHI) indicates that the benefits of hormone replacement therapy on osteoporosis outweigh the risks for women who are in their 50s and 60s.
references
Munk-Jensen N, Pors Nielsen S, Obel EB, Bonne Eriksen P. Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study. Br Med J (Clin Res Ed) 1988; 296:1150. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004; 291:1701.
